Probabilistic modelling of gait for robust passive monitoring in daily life

Passive monitoring in daily life may provide invaluable insights about a person's health throughout the day. Wearable sensor devices are likely to play a key role in enabling such monitoring in a non-obtrusive fashion. However, sensor data collected in daily life reflects multiple health and behavior related factors together. This creates the need for structured principled analysis to produce reliable and interpretable predictions that can be used to support clinical diagnosis and treatment. In this work we develop a principled modelling approach for free-living gait (walking) analysis. Gait is a promising target for non-obtrusive monitoring because it is common and indicative of various movement disorders such as Parkinson's disease (PD), yet its analysis has largely been limited to experimentally controlled lab settings. To locate and characterize stationary gait segments in free living using accelerometers, we present an unsupervised statistical framework designed to segment signals into differing gait and non-gait patterns. Our flexible probabilistic framework combines empirical assumptions about gait into a principled graphical model with all of its merits. We demonstrate the approach on a new video-referenced dataset including unscripted daily living activities of 25 PD patients and 25 controls, in and around their own houses. We evaluate our ability to detect gait and predict medication induced fluctuations in PD patients based on modelled gait. Our evaluation includes a comparison between sensors attached at multiple body locations including wrist, ankle, trouser pocket and lower back.