Efficient Reconstruction of Stochastic Pedigrees
May 08, 2020 Β· Declared Dead Β· π arXiv.org
"No code URL or promise found in abstract"
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Authors
Younhun Kim, Elchanan Mossel, Govind Ramnarayan, Paxton Turner
arXiv ID
2005.03810
Category
cs.DS: Data Structures & Algorithms
Cross-listed
cs.LG,
q-bio.PE,
q-bio.QM,
stat.ML
Citations
1
Venue
arXiv.org
Last Checked
4 months ago
Abstract
We introduce a new algorithm called {\sc Rec-Gen} for reconstructing the genealogy or \textit{pedigree} of an extant population purely from its genetic data. We justify our approach by giving a mathematical proof of the effectiveness of {\sc Rec-Gen} when applied to pedigrees from an idealized generative model that replicates some of the features of real-world pedigrees. Our algorithm is iterative and provides an accurate reconstruction of a large fraction of the pedigree while having relatively low \emph{sample complexity}, measured in terms of the length of the genetic sequences of the population. We propose our approach as a prototype for further investigation of the pedigree reconstruction problem toward the goal of applications to real-world examples. As such, our results have some conceptual bearing on the increasingly important issue of genomic privacy.
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