Efficient Reconstruction of Stochastic Pedigrees

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Authors Younhun Kim, Elchanan Mossel, Govind Ramnarayan, Paxton Turner arXiv ID 2005.03810 Category cs.DS: Data Structures & Algorithms Cross-listed cs.LG, q-bio.PE, q-bio.QM, stat.ML Citations 1 Venue arXiv.org Last Checked 4 months ago
Abstract
We introduce a new algorithm called {\sc Rec-Gen} for reconstructing the genealogy or \textit{pedigree} of an extant population purely from its genetic data. We justify our approach by giving a mathematical proof of the effectiveness of {\sc Rec-Gen} when applied to pedigrees from an idealized generative model that replicates some of the features of real-world pedigrees. Our algorithm is iterative and provides an accurate reconstruction of a large fraction of the pedigree while having relatively low \emph{sample complexity}, measured in terms of the length of the genetic sequences of the population. We propose our approach as a prototype for further investigation of the pedigree reconstruction problem toward the goal of applications to real-world examples. As such, our results have some conceptual bearing on the increasingly important issue of genomic privacy.
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