CosinorAge: Unified Python and Web Platform for Biological Age Estimation from Wearable- and Smartwatch-Based Activity Rhythms

Every day, millions of people worldwide track their steps, sleep, and activity rhythms with smartwatches and fitness trackers. These continuously collected data streams present a remarkable opportunity to transform routine self-tracking into meaningful health insights that enable individuals to understand -- and potentially influence -- their biological aging. Yet most tools for analyzing wearable data remain fragmented, proprietary, and inaccessible, creating a major barrier between this vast reservoir of personal health information and its translation into actionable insights on aging. CosinorAge is an open-source framework that estimates biological age from wearable-derived circadian, physical activity, and sleep metrics. It addresses the lack of unified, reproducible pipelines for jointly analyzing rest-activity rhythmicity, physical activity, and sleep, and linking them to health outcomes. The Python package provides an end-to-end workflow from raw data ingestion and preprocessing to feature computation and biological age estimation, supporting multiple input sources across wearables and smartwatch. It also makes available trained model parameters (open weights) derived from large-scale population datasets such as UK Biobank, enabling reproducibility, transparency, and generalizability across studies. Its companion web-based CosinorAge Calculator enables non-technical users to access identical analytical capabilities through an intuitive interface. By combining transparent, reproducible analysis with broad accessibility, CosinorAge advances scalable, personalized health monitoring and bridges digital health technologies with biological aging research.