Serialized EHR make for good text representations
October 11, 2025 ยท Declared Dead ยท ๐ arXiv.org
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Authors
Zhirong Chou, Quan Qin, Shi Li
arXiv ID
2510.13843
Category
cs.CL: Computation & Language
Cross-listed
cs.AI
Citations
1
Venue
arXiv.org
Last Checked
5 months ago
Abstract
The emergence of foundation models in healthcare has opened new avenues for learning generalizable representations from large scale clinical data. Yet, existing approaches often struggle to reconcile the tabular and event based nature of Electronic Health Records (EHRs) with the sequential priors of natural language models. This structural mismatch limits their ability to capture longitudinal dependencies across patient encounters. We introduce SerialBEHRT, a domain aligned foundation model that extends SciBERT through additional pretraining on structured EHR sequences. SerialBEHRT is designed to encode temporal and contextual relationships among clinical events, thereby producing richer patient representations. We evaluate its effectiveness on the task of antibiotic susceptibility prediction, a clinically meaningful problem in antibiotic stewardship. Through extensive benchmarking against state of the art EHR representation strategies, we demonstrate that SerialBEHRT achieves superior and more consistent performance, highlighting the importance of temporal serialization in foundation model pretraining for healthcare.
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